The study aimed to review the CRISPR research trend by covering major historic milestones in its research development from 2005 to date. The data from Scopus considered for this evidence-based scientometric study. Nine thousand four hundred eighty-nine data were extracted and analyzed for publications, sources, authors, affiliations, countries, and keywords based on different scientometric tools using MS Excel and other scientometric software viz. Biblioshiny (RStudio), VOSviewer. The findings showed the content and research direction of the area and have helped us identify the current situation and find the most productive teams in this field. The co-citation analysis identified the highly cited reference. The cluster analysis and timeline helped to recognize the structure and evolution of this research.